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In addition to a potentially direct antioxidant activity, curcumin can induce the expression of phase II antioxidant enzymes, including glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis

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What Research Says About Antioxidant Supplementation Timelines Generally Glutathione's weeks-based timeline for visible skin effects is consistent with the broader pattern seen across oral antioxidant and nutrient supplementation research generally vitamin C, collagen peptides, and other ingestible skin-support compounds also show published timelines in the 6-12 week range for visible effects, because they all ultimately depend on the same skin cell renewal biology rather than acting as instant topical treatments